Adenocarcinoma - Causes, Symptoms, Prevention, Treatment

Adenocarcinoma defined by the presence of tubercles or papillae within the tubular-iron complexes. The direction of histological differentiation of the cells Clara characterized by the appearance in cancer epithelial cells with eosinophilic cytoplasm clavate-shaped process on the apical surface. Differentiation in the pneumocytes of the second type of adenokartsi nome can be identified by intranuclear eosinophilic inclusions and positive staining of the cytoplasm luksolevym solid blue and Sudan.

Solid adenocarcinoma is virtually identical to large-cancer, if not the intracellular mucus, painted mutsikarminom, diastazorezistentnoy PAS (PAS)-reaction or altsianovym blue. Around one third of observations noma cells express adenokartsi tsitoksratiny, epithelial membrane antigen, vimentin, and about 1/3 - apoprotein surfactant. Parenchyma bronchopulmonary adenokartsi noma is able to give a positive reaction to a lot of neuroendocrine markers: neuron-specific enolase, Leu-7, chromogranin and sinaptofizin. Occasionally there is the expression of bombesin, calcitonin, serotonin, adrenocorticotropic hormone, vasopressin, S100-protein, protein, cells Clara.

Poorly differentiated adenocarcinoma often has a loose band of growth of cancer cells that are actively germinating stroma. Large polygonal cells such tumors have a high nuclear-plasmatic ratio.

Strom conventional adenocarcinoma looks different - it is loose, then tight and fibrozirovanny matrix. In some cases, formed a dense lymphoid infiltrate, which may even hide the epithelial structure and simulate lymphoma. Granulomatous reaction occurs and sarcoid type with multinucleated giant cells.

Parenchyma unusual adenocarcinoma differentiated in the direction of signet ring cell, mucinous (colloid), re-patoidnoy, "intestinal" carcinoma. The diagnosis of adenocarcinoma of the transparent cell is placed when the cells occupy more than half of the cancer parenchyma. Cells of adenocarcinoma contain a large amount of glycogen,

Bronchopulmonary adenocarcinoma should be differentiated from reactive changes and metallasticheskih epithelium skleroziruyushey hemangioma, alveolar adenoma, papillary adenoma of the pneumocytes of the second type of atypical adenomatous hyperplasia, bronchiolar-alveolar adenomas, kartsinoila with glandular structures, atypical carcinoid, large-neuroendocrine cancers and metastatic lesions.

Reference - What is Adenocarcinoma by Carcinoma Types.